Desenvolvimento de sistemas de liberação controlada quitosana/opióides para uso pós-cirúrgico.

Abstract

In conventional drug therapy, the drug is administered in a dosage form and produces a tissue level of the drug is not maintained within the therapeutic range over an extended period of time. The importance of the release of active principles stems from the fact that a drug can rarely achieve a specific target in the body in adequate concentrations to cause the expected therapeutic effect systems. An ideal drug delivery system should be biocompatible , easily released , allowing a control of the rate of drug delivery and should not alter the activity of the drug distribution lately chitosan has gained wide space between the materials used in the manufacture of these systems meet these needs . Based on the above this study aimed to develop a system of controls release of fentanyl parti membrane Chitosan / Fentanyl in the proportions of 5 , 3 and 1 % drug . Fentanyl was added to chitosan solution and subjected to drying the solvent to form the membranes , they were characterized to assess the drug / polymer interactions. It was observed that the addition of fentanyl appropriated Crystalline membranes , making them less susceptible to biodegradation in vitro. The final structures had become rough and small grains scattered on its surface , these grains that were considered contaminants originating from industrial processing of the drug . There was a decrease in hydrophilicity directly proportional to the increase of drug concentration and showed no toxicity. Given the above it can be concluded that the methodology used for the synthesis of membranes Chitosan / Fentanyl appeared to be effective . Analyses suggest the presence of fentanyl in the synthesized membranes causing changes in its degradability , could be a promising material for use in controlled release drug delivery systems .