Hidróxido duplo lamelar / dipirona: estratégia de síntese, caracterização e estudo de liberação de fármaco.

Abstract

Lamellar Double Hydroxides (HDL) have interesting properties and wide applicability and can be used for catalysis, medicinal use and as adsorbent material. These solids have two- dimensionally arranged structures with flexible coverslips. The present work aimed to synthesize and characterize modified HDLs with pharmacological molecules, to evaluate the drug release process and its thermal stability in the hybrid structure. For the HDL synthesis of the Cu-Zn-Al system, the direct method of co-precipitation at variable pH was used from solutions containing the metallic cations. For the synthesis of HDL-Drug, the already synthesized HDL was taken, and with it still wet, it was added to an alcoholic solution of dipyrone, remaining there until the total evaporation of the solution. The characterization of solids was performed by X-ray diffraction and infrared spectroscopy analysis. Emission tests were performed by adding 250 mg of HDL-Drug to 200 cm -3 of distilled water under constant agitation. Subsequently, 10 cm -3 aliquots were taken at intervals of 10 to 60 minutes for 7 hours of assay. Aliquots taken from the system were analyzed by UV / Vis spectroscopy. From the study, it was possible to obtain the formation of HDL Cu system, Zn, Al and HDL with drug molecules in its structure, called HDL-Dipyrone. The synthesized solid presented controlled release of the drug during the analyzed period, besides a higher thermal stability.