Avaliação da atividade antifúngica do benzil 2,3-didesoxi-a-D-eritro-hex-2-enopiranosídeo contra Candida spp.

Abstract

In recent decades, the number of people with invasive fungal infections has increased dramatically worldwide. These infections are often difficult to detect and treat and therefore pose a major threat to human health due to their significant morbidity and mortality rates. The genus Candida spp. It comprises microorganisms that cause invasive fungal infections, Candida albicans being the most prevalent species, whose its relative incidence in infection is declining due to the increasing prevalence of other species, such as C. glabrata, C. tropicalis and C. parapsilosis. Therefore, this study aimed to investigate the antifungal activity of 2,3-unsaturated glycoside and its association with amphotericin B against Candida spp. The antifungal activity of 2,3-unsaturated glycoside was evaluated by broth microdilution technique, having been observed that it did not show antifungal activity for most Candida spp. used in the study. The combination of this substance with amphotericin B was performed by the checkerboard method, and when associated with amphotericin B the result was classified as indifferent. Thus, it is the alternative to carry out further studies and modifications to the 2,3-unsaturated glycoside molecule to improve its activity against various fungi.