Avaliação toxicológica das apresentações de ácido acetilsalícilico e paracetamol frente á Artemia Salina Leach.

Abstract

Over the last few years the pharmaceutical industry has grown rapidly, as a result the number of poisonings has increased proportionately, partly due to the indiscriminate sale of drugs. In Brazil, 25% of cases of poisoning are due to drugs, thus, it is necessary to monitor the storage, sale and use of them to obtain information for the safety of world health. It is noteworthy that among the most intoxicating drugs are analgesics, antipyretics and anti-inflammatory drugs, since they are widely prescribed due to their therapeutic indication and because they are over-the-counter drugs. In this context, among the various methodologies used for toxicity studies, we highlight the bioassay with Artemia salina Leach, which has a model organism for toxicity evaluation. Thus, the objective of this study was to evaluate the toxicity of the following drugs against Artemia salina L.: acetylsalicylic acid and acetaminophen. Decapplicate tests of these excipient-free and with excipients drugs (generic and reference) were performed to determine the percentage of lethal concentrations at 10%, 50% and 90% using the POLO-PC software. The toxicity evaluation of acetylsalicylic acid and acetaminophen presentations was moderately toxic in relation to the Artemia salina L bioassay. It is concluded that the bioassay with Artemia salina L. was useful to establish results with information that serves as monitoring of drug toxicity, ensuring the safety of the population.