Avaliação da atividade antifúngica do derivado de carboidrato enônico contra fungos do gênero Aspergillus spp.

Abstract

Fungal infections are a growing problem in public health, as fungi are beings with a clinical spectrum, in addition to being opportunistic and can cause the most varied levels of severity, from something superficial to the same systemic, reaching vital organs, increasing levels of morbidity and mortality of those belonging, which has a major impact on human health. The genus Aspegillus spp. comprises several species, among these several species in a pathogenic process and with a higher rate of prevalence of infection, A. fumigatus followed by other species such as A. flavus. Therefore, this study aimed to investigate the potential of the antifungal activity of the enonic carbohydrate derivative and its association with amphotericin B against Aspergillus spp. The antifungal activity test was carried out using the broth microdilution method, and its antifungal efficacy against Aspergillus spp. Strains was observed, inhibiting the growth of microorganisms. In association with amphotericin B using a checkerboard technique, it was seen that its combination resulted in classification as an antagonist. In this study, the effectiveness and biological potential of the antifungal activity towards the tested compound, the enonic carbohydrate derivative, were concluded. However, studies should be carried out so that there is an improvement through the modification of the molecule, generating a possible increase in its spectrum of action and synergistic compatibility with other substances.