Uso terapêutico da cannabis com ênfase em pacientes com parkinson: uma revisão bibliografica.

Abstract

Cannabis Sativa is a plant with the popular name in Brazil for marijuana, and best known due to its psychoactive effects, despite this leading to distorted and misperceptions, generating an aversion to Cannabis, which has great medicinal potential. Its pharmacological potential is linked to the secondary metabolites present in the plant, whose main attention is turned to cannabinoids. Studies show the therapeutic efficacy of the compounds tetrahydrocannabidiol (THC) and cannabidiol (CBD), as well as the entourage effect of the other natural products present in the species, for the treatment of various diseases. Aided by the knowledge that they act in the endocannabinoid system, this being an important synaptic modulator involved in motor, cognitive and emotional behavior. Among these therapeutic uses, we highlight the application in the main adversities caused by Parkinson's. Therefore, this work aimed to investigate and critically analyze the contributions of scientific studies on Cannabis Sativa, as well as to scientifically demonstrate the efficacy and characterization of Cannabis against Parkinson's disease. The research was carried out using the databases, Capes Periodicals, Scientific Eletronic Library Online (SciELO), Science Direct, PubMed, database of the Federal University of Pernambuco (UFPE), 14 articles were found related to the effectiveness of Cannabis Sativa in the treatment for Parkinson's. Studies show therapeutic efficacy due to the role of phytocannabinoids in motor changes, non-motor symptoms and great potential for neuroprotection. Therefore, Cannabis sativa is an excellent therapy for the treatment of Parkinson's disease, since the usual long-term therapy is limited, as the beneficial effects tend to decrease with the progression of the disease, and patients usually present with motor instability and drug-related problems.