Obtenção e avaliação de filmes de quitosana/gelatina para liberação de midazolam.

Abstract

The use of anxiolytics has grown in recent years worldwide, as one of the most recurrent problems in the world population is anxiety and sleep disorders. The development of new drug delivery systems becomes increasingly important in promoting therapeutic actions in order to reduce the limitations in existing therapies. Therefore, the use of polymers such as chitosan, which exhibit characteristics of biodegradability, biocompatibility, mucoadhesion, associated with other polymers such as gelatine, is presented as a viable alternative to obtain a controlled release system of several drugs, including benzodiazepines. Thus, the present work aimed to obtain Chitosan / Gelatin films for the release of Midazolam. The films were prepared by the solvent evaporation method, by dissolving the chitosan in acetic acid (1% v / v), to a final concentration of the polymer solution (1% m / v), followed by the incorporation of gelatin (20% m / m) and Midazolam (0.03mg / ml). After obtaining the films were characterized using MO, DRX, FTIR, Degree of Swelling, Biodegradation and Wettability by Contact Angle Measurement. In OM, uniform and dense surfaces were observed in the material. In the XRD assay it can be confirmed that the incorporation of the drug and gelatin in the chitosan solution led to the reduction of film crystallinity. In the FTIR assay the interaction of the drug and gelatin with the hydroxyl and amine groups of the chitosan was evidenced. As to the degree of swelling, a greater increase of the samples with the drug was observed. In the biodegradation analysis, it was observed that it is influenced by the addition of gelatin and mainly by the drug. The Wettability results showed that the material has a hydrophilic character and that the incorporation of the drug enabled the increase of the hydrophilicity of the same. It was observed that the system presented homogeneity, adequate chemical interaction between the constituents and it was possible to obtain Chitosan / Gelatin films incorporated with Midazolam. Thus, it is concluded that the films present potential for use in the midazolam release system, with the use of biodegradable biomaterial with anxiolytic action.