Avaliação dos efeitos comportamentais de filhotes provenientes de ratas submetidas a uma dieta de cafeteria e à suplementação com óleo de cártamo.

Abstract

lncreasing the consumption of diets of cafcteria for young women of reproductive age.The malemal diet in the first trimester of pregnancy is very important for the development and differentiation of various fetal organs. Polyunsaturated fatty acids Omega 3 (AGPI ro-3)and Omega 6 (AGPT ro-6) stand out for having beneficiai affects to human health , including pregnancy period. Significant amounts of AGPJ are found in safflower oi! and has been used during pregnancy and lactation dueto the presence ofthe omegas in its constitution. This way the objective of this work was to evaluate the behavioral effects of pups from female mouse subjected to a diet of cafeteria during pregnancy and Jactation supplemented with safflower oi!. Primiparous females,Wistar mouses, with 90 days of life and weight of250 ±50 g were used to obtain the pups .Four groups were formed for the female mouses: a control group receiving standard diet and distilled water ; Obesity group receiving diet of cafeteria and distilled water by gavage , the Obesity group + Samower receiving the diet of cafeteria and safflower oil and the control group +safflower, receiving the standard diet and safflower oil. After weaning. the litters were standardized to 8 groups, and again were formed four groups according to thc mothers , group (Group C) , the Obesity Group (Group OB) ,Obesity Group + Safllower (Group OB +CT) ,(Group C+CT) .Were carried out two tests: the test of open field and the maze test in high cross. Among the parameters analyzed in the pen field test , the number of variation and the amount of lift in obesity and Obesity + Safllower was lower when compared to the control group and the control group+ Safflower .The Obesity Group had greater self-cleaning time when compared to the control group and Controi+Safflower (P<0,05)and was no diffcrence between the groups for the parameter of defecation. The test of the mazc at high cross , the Obesity group + Saffiower also entered more times in with open arms, compared to the Obesity group (P <0, 05), but also stayed longer in with open arms . Alrcady in the arms closed, lhe Obesity group cntered less when compared to other groups and there was no difference in the group for the time parameters in the arms closedand

time in the central area. Therefore, this work demonstrated that consumption of the diet of cafeteria during pregnancy and lactation decreased locomotor activit} /exploratory,causing a ansiogênico ctTect in the ofTspring in the test CA and that supplementation with saffiower oil provoked an anxiolytic in testing the ICE.