O potencial antimicrobiano do carveol: uma revisão integrativa.

Abstract

Carveol (C10H16O) is a monocyclic monoterpene, which contains in its molecular formula a secondary alcohol. Studies present in the available scientific collection prove the effectiveness of this phytoconstituent to several pharmacological activities, among them, the antimicrobial one stands out. In view of this, this study aims to carry out a literature review about the antimicrobial potential of carveol. This is an integrative review between the years 2010-2021 in the BVS, PubMed, Scielo, ScienceDirect and Web of Science databases. Of the 2998 articles retrieved from the databases, only 5 were selected to compose the results, which the most studied genera included Candida, Staphylococcus and Escherichia. The broth microdilution technique was the most used methodology to determine its action. Regarding MIC, for most species, they were excellent. About the Time-kill assay, carveol had excellent performance at the concentration of 4 x MIC, which showed a reduction of CFU by 6 log in 2 hours. No study was found in the literature about the use of the Checkboard method. Furthermore, this compound had a good antibiofilm activity against the bacteria, Staphylococcus aureus. As for the possible mechanism of action of the antimicrobial activity of carveol, it is due to the serious damage caused to the cytoplasmic membranes, which will promote cell lysis. Thus, few studies in the available scientific collection address the subject, making it necessary to carry out more in vitro and in vivo studies for a better elucidation of its action.