Avaliação da influência do tratamento da doença periodontal sobre os níveis séricos de proteína C reativa.

Abstract

There is a growing body of evidence linking systemic inflammation to oral microbial virulence factors, which penetrate the systemic circulation. This evidence is supported by the high serum levels of C-reactive protein (CRP) and other acute phase markers in patients with chronic periodontitis. The present study aimed to investigate the influence of periodontal disease on the serum levels of C-reactive protein (CRP), evaluating the levels of this biomolecule in patients with and without periodontal disease and, in those with periodontal disease, evaluating the levels of this protein before and after periodontal treatment. The research was carried out with 82 patients treated at the Clinic-School of Dentistry of the Federal University of Campina Grande, Patos-PB campus. The individuals were divided into two groups, one consisting of 42 patients with healthy periodontium and the other consisting of 40 patients with periodontal disease. Among the individuals in the periodontal disease group, 11 were reassessed one week after completion of periodontal treatment. CRP concentrations were significantly higher in the periodontal disease group (6.09 ± 1.34 mg/l, n = 40) compared to the control group (2.93 ± 0.55 mg/l, n = 42) . The results also showed that periodontal treatment reduced CRP values (3.76 ± 0.92 mg/l, n = 11) when compared to values prior to treatment (10.58 ± 3.69 mg/l, n = 11), however, with no statistically significant difference. It is observed that CRP levels are significantly increased in the serum of patients with periodontal disease in relation to patientswith healthy periodontium, corroborating the influence of periodontal disease on systemic levels of the inflammatory response. In line with previous reports, lower CRP levels were observed after nonsurgical periodontal therapy. The results indicate that periodontal disease interferes with serum levels of CRP, and that periodontal treatment may have a positive effect on the reduction of this protein.