Correlação clínica laboratorial da cinomose, erliquiose e leishmaniose com a ceratoconjuntivite seca em cães.

Abstract

Clinical laboratory correlation of distemper, ehrlichiosis and leishmaniasis with keratoconjunctivitis sicca in dogs. The keratoconjunctivitis Sicca (CCS) also known as "dry eye" is a common occurrence of illness in veterinary ophthalmology particularly in companion animals, where dogs are the most affected. It is characterized by reduction of the aqueous portion of the tear film causing inflammation and dryness of the cornea and conjunctiva, ocular discomfort and reduced visual acuity. The aim of this study is to correlate the hematologic and biochemical findings of dogs with distemper, Ehrlichiosis and Leishmaniosis with developing mechanisms of keratoconjunctivitis sicca. We used eight dogs treated at the CMPA sector of the Patos-PB CSTR Veterinary Hospital Federal University of Campina Grande, with clinical picture symptoms suggestive of keratoconjuntivite sicca. These suspects dogs were referred to perform the Schirmer Tear Test, were considered positive those presented below 15 mm/min. Subsequently all positive dogs to screening test were submitted to serological analysis, hematological and biochemistry to determine the etiologic agent involved in the infection. Among 8 animals diagnosed with CCS, 3 (6%) had ehrlichiosis, 3 (6%) with canine distemper and 2 (4%) leishmaniosis. Analyzing data from blood tests of these eight animals with CCS we checked that, normochromic normocytic anemia, neutrophilia, eosinopenia and thrombocytopenia were the most frequent hematological changes. Since the biochemical changes, the most common were hypoalbuminemia, hyperglobulinemia and azotemia indicating renal involvement due to infectious disease. Associating the hematological and biochemical changes distemper, ehrlichiosis and leishmaniosis with the manifestation of SCC, it is suggested an involvement of immune-mediated aspect since the production of antibodies against distemper agent, Ehrlichia and Leishmania form immune complexes that deposit in tissues, triggering an answer infiltration around the ducts of the lacrimal glands causing the CCS.