Influência do tratamento com doxiciclina associada ou não à prednisolona sobre os parâmetros hematológicos e proteinograma sérico de cães com erliquiose.

Abstract

Influence of treatement with Doxycycline or not associated to Prednisolone on haematological and serum proteinogram of dogs with ehrlichiosis. The objective of this study was evaluate comparatively the effects of treatment with doxycycline hydrochloride associated or not with prednisolone on the haematological parameters and serum proteins in dogs diagnosed with Ehrlichia canis at different times. In Small Animal Medical Clinic/Veterinary Hospital/ UFCG, 10 dogs diagnosed with ehrlichiosis by clinical examination, blood tests and serology test, (with antibodies anti Ehrlichia canis) were selected and assigned into two groups, with five animals each, denominated GD and GDP. The GD group was treated with doxycycline (5 mg / kg P.O. BID for 28 days) and the GDP group was treated with doxycycline using the same dose e period, associated to prednisolone (2mg/kg P.O. BID for 5 days). During the treatment period, blood samples were collected at different times, day 0 (M0), with 10 days (M10), one with 21 days (M21) and the other in conclusion of treatment with 28 days (M28). From the blood samples and serum collected at different times were performed erythrogram, leukogram, platelet count and proteinogram (dosage of total proteins, prealbumin, albumin, alpha 1, alpha 2, beta and gamma globulins and C­reactive protein), in the Clinical Pathology Laboratory/ Veterinary Hospital/UFCG. The results with normal distribution were submitted to Tukey test (p<0.05). By comparing the GD and GDP treatments, it was observed that both treatments promoted a discrete and similar response of haematological parameters in the different moments. Thrombocytopenia was observed in both groups, but the GDP has demonstrated better response to treatment, with tendency curve increasing of the average . In the leukogram, although some parameters have presented statistical difference (p <0.05) between the groups, all the values were within the reference values, except for lymphopenia observed in GDP treatment, fact expected due to glucocorticoid action. In the proteinogram, no effect was observed in GDP treatment (p> 0.05) on the different times, but the total protein and globulin values that were above the reference values at the start of treatment, returned to reference value. The results showed that both treatment protocols resulted in improvement of clinical, hematological and proteinogram parameters, however, the use of Prednisolone has not shown more benefits than the separate administration of doxycycline.