Efeitos da suplementação com vitamina E sobre a eletrocardiografia e metabolismos cardíaco e oxidativo em felinos domésticos.

Abstract

Effects of supplementation with vitamin E on electrocardiography, cardiac oxidative metabolism and in domestic cats. The objective of the research was to investigate the antioxidant efficiency of vitamin E (dL-alpha-tocopherol), supplemented orally, on the following parameters: physiological, hematological, serum biochemistry, electrocardiography, cardiac metabolism and oxidative in adult cats without breed. Was used 16 cats, clinically healthy, divided into two equal groups: one consisting of control animals (GC); and another by animals supplemented with vitamin E at a dose of 40 UI/kg day, forming the

experimental group (GE). The experiment lasted 60 days; the first 15 called pre- experimental period, in which the animals were dewormed, received balanced

commercial diet and water ad libitum. On the day15 the first data collection was carried out; it was named M0, which provided the reference values, forming the GC. Posteriorly, began the 45 days of vitamin E supplementation, evaluated by collecting periodic data, at 15 days intervals, forming GE moments, respectively M1, M2 and M3. Was evaluated the physiological parameters, heart rates (FC) and respiratory rate (FR) and body temperature (TC). It was held hemogram, serum biochemistry, and electrocardiography.

Data were subjected to analysis of variance for "K" independent parametric or non- parametric samples and descriptive analysis (p≤0.05). It was observed leukocytosis at

M3 and a slight increase in ALT at M2; there was a statistically significant difference between M0 compared to M1 and M2 for PPT variable and M0 to M2 in relation to globulins. In electrocardiography, cats tested showed values in the normal range for the species not being observed statistically significant difference between any of the experimental groups. Regarding creatine kinase isoenzyme MB (CK-MB) was statistically significant difference in M0 compared to M1 and M3. There was no statistically significant difference between the groups in relation to malondialdehyde values (MDA); nevertheless was observed a decrease in the average values of M1 and M2 in relation to M0. It is concluded that vitamin E supplementation in confined cats had no influence on blood, physiological and neither electrocardiographic parameters. Increasing the concentration of y-globulins. The use of CK-MB as cardiac marker is important to evaluate the antioxidant capacity of vitamin E.