Uso da membrana biossintética de hidrogel com nanoprata em feridas cutâneas em coelhos.

Abstract

Use of nanosilver hydrogel biosynthetic membrane in skin wounds in rabbits. The animals are subject to various factors that lead to tissue damage, causing Veterinarians seek alternatives to accelerate the tissue repair process, increasing the ability of cells to perform its function. The hydrogel with nanosilver membrane assist in treatment of skin wounds providing the best development of granulation tissue, since that stimulates the cicatricial process and has favorable characteristics to the reduction or inhibition of contamination of wounds, due to the presence of silver. The objective of this study was to evaluate clinically and histologically the skin healing, using hydrogel with nanosilver membrane in open wounds in New Zealand rabbits, at the slaughter stage. Were used 18 rabbits in what were removed two skin segments (1 cm²), creating two dorsal wounds, one on each side of the column line. The left wound was treated in the conventional mode (control group - CG) and the right wound was treated with the implantation of the hydrogel with nanosilver membrane, being considered as treatment group (TG). Were carried out clinical histopathological analysis, whose results showed that for neovascularization and fibroblast number the TG wounds showed a greater intensity than the CG wounds; and in none of the wounds of both groups were found epithelioid macrophages. The hydrogel with nanosilver membrane it favors tissue healing and can be used in open skin wounds, without undesirable changes.