Anestesia de cutias (Dasyprocta prymnolapha) com Cetamina S e Midazolam.

Abstract

The objective was to verify the application of Ketamine S and Midazolam association in order to pharmacologically contain black-humped Agoutis (Dasyprocta prymnolopha) and the effects of this procedure over the physiological parameters, and over the electrocardiogram of those animals. This study was performed in similar conditions to those found in captivity of wild animals or in zoos. It utilized previous monitoring, which allowed to compare the base values of this study with others conducted on the same species, and with continuous monitoring of the animals, aiming to grant a better amount of safety to the procedure, as well as the observation of variables in an immediate and accurately manner. For the study nine black-humped Agoutis, adult, healthy, with variable weight of 1.5 kg to 2 kg were utilized provided from the Wild Animals Production and Research Center (NEPAS) of the Federal University of Piauí, Teresina-PI Campus. The animals were kept in an adapted environment of 24m2 of covered area, light and natural ventilation, mixed floor of cement (16 m2) and sand (8 m2) and with environmental enrichment of masonry lairs and plants. The food available to the animals was extruded ration and ad libitium water. All physiological and electrocardiographic parameters were assessed and recorded before the drug application, being this considered the basal moment (M0). At first were assessed the cardiac frequency (FC), respiratory frequency (FR), body temperature (TC), oxyhemoglobin saturation (SpO2), systolic blood pressure (PAS) and the electrocardiographic tracings. Soon after the association of Ketamin S and Midazolam, in the same syringe, was administered by intramuscular route at the dosages of 15 mg/kg and 0.5 mg/kg, respectively. Successive evaluations occurred every 10 minutes over a period of 40 minutes (M10, M20, M30, M40). Regarding anesthesia, were observed: the latency period, which was understood as the time interval between the end of the drug administration and loss of reflexes; the available anesthetic period, the time between the final latency period until the spontaneous lifting of the head; and the anesthetic recovering period, which was considered as the final interval between the final available anesthetic period and the beginning of spontaneous ambulation. The results showed that the association caused little to no significant alterations to the physiological parameters, except the FR which was considerably reduced, as the consequent SpO2 reduction, compensated throughout the study. Regarding electrocardiographic parameters, there was significant alteration on the duration of the interval P-R when compared to M0 and M40. No significant alteration was found on the morphology of the electrocardiographic tracings obtained during the experiment. The anesthesia assessment showed that the animals had an average latency period of two minutes, average available anesthetic period of 81 minutes, and average total recovering time of 111 minutes. It was concluded that the protocol showed itself as efficient, in a manner that provided an anesthesia of good duration and minimally altered the evaluated physiological parameters.