Avaliação da migração cranial de diferentes volumes de Iohexol, administrados pela via epidural lombossacra, em cães (Canis familiaris).

Abstract

Evaluation of cranial migration of different volumes of Iohexol, administered by the lumbosacral epidural route, in dogs (Canis familiaris). The aim of this research is determinate the migration obtained with the administration of different volumes of iohexol by epidural-lumbosacral access, as well its effects over some physiological variables, in dogs. It was used 10 dogs, 5 males and 5 females, at 2.2±1.2 years old, weighting 12.6±3.2 kg. The animals was medicated with IV acepromazine (0.1 mg/kg), followed, 15 minutes later, by IV propofol (2.5 mg/kg). After 5 minutes was administered 0.25 mL/kg (Group - G1) or 0.4 mL/kg (Group - G2) of iohexol 150 mgI/mL, by epidural access. It was evaluated the cranial contrast migration, heart rate (HR), P wave, P-R interval, QRS complex and Q-T interval durations, respiratory rate (f) and body’s temperature (TºC). The animals don’t show adverse effects to iohexol. On G1 the contrast migrated as middle at T11 (24.3±3.7cm) and on G2 at T9 (27.0±2.0), with no statistic significance between the groups. HR and P wave, P-R interval, QRS complex, and Q-T interval durations, don’t varied significantly. Respiratory rate reduced since the moment T0 in both groups, which remain trough the experimental period. The body’s temperature reduced starting from T20 on the second group (G2), on G1 tended to reduce, but no statistic significance was noted. It was concluded that the 0.4 mL/kg dose is potentially more indicated, when the use of local anesthetic, to blockade the ventral abdominal region; that iohexol does not change the physiological variables studied and that the iohexol concentration of 150 mgI/mL is satisfactory for the accomplishment of the epidurografy.