Avaliação de hidroxiapatita, quitosana e células da medula óssea na regeneração de defeito provocado na metáfise femoral de coelhos (Oryctolagus cuniculus), estudo clínico-cirúrgico e radiológico.

Abstract

The objective was to evaluate the effectiveness of hydroxyapatite and cystotan implants and their association with bone marrow cells in the regeneration of the femur of rabbits. Hydroxyapatite (HA) and chitosan cylinders isolated and associated with bone marrow (BM) were evaluated. '6 rabbits, male and female, young, New Zealand, weighing on average 2.5g were used. Holes were made in the femoral metaphysis in the distal and proximal part of it. Bone substitutes were inserted into holes in the following order: cystotan in the proximal metaphysis and hydroxyapatite in the distal metaphysis in the left pelvic limb and in the right pelvic limb in the same order with addition of bone marrow over the biomaterials. It was evaluated clinically during the first 10 days and radiologically at the following times: immediately before and after the surgeries, 30 and 60 days. Chitosan and HA, when associated with bone marrow, promote greater radiopacity followed by chitosan and HA alone.