Concentrações séricas de creatina e dimetilarginina simétrica como biomarcadores renais em felinos.

Abstract

Chronic kidney disease is a distinct disease in older cats, which compromises the quality and reduces the life expectancy of the patient. The importance of diagnosing kidney disease led to early work, which aimed to evaluate serum concentrations of creatinine and symmetric dimethylarginine biomarkers in felines attended the University Veterinary Hospital Prof. Dr. Ivon Macêdo Tabosa, the Federal University of Campina Grande (HVU-UFCG), Patos Campus - PB. They were included in this study eight adult cats 5 ± 13 years, four males and four females, weighing 2.9 ± 5kg selected from certain prerequisites; the first would be with regard to age, where it should be longer than five years (aged five to seven years, from eight to ten years old and 11-13 years) and the other requirement for the clinical manifestations, whose cats should not show signs of kidney disease. Obtaining records at the Medical Clinic of Small Animals (CMPA), the HVU-UFCG, was to evaluate the physiological parameters (heart and respiratory rate, and body temperature). For peripheral or central venipuncture collected 2 ml of blood being accommodated in the same eppendorf without anticoagulant. Subsequently, the samples were sent to the Clinical Pathology Laboratory UVH-UFCG then centrifuged to obtain blood serum, where the serum creatinine dosage would be performed. Part of serological sample was frozen (-20 ° C) for later analysis of symmetric dimethylarginine (SDMA). The results were analyzed descriptively of biomarkers, relating to age, body condition score (BCS) and creatinine values and SDMA. After selection for the study, 25% of cats were grouped in the age group of five to seven years of age, 37.5% between eight to 10 years and 37.5% between 11 to 13 years old. Among the records relating to the observed creatinine values of 0.6 mg / dL to 1.9 mg / dL; He showed only a couple feline higher than the reference for the species, which was 1.9 mg / dL. In SDMA test, the same animals that presented high concentrations for creatinine, gave the highest value of SDMA (19μg / dL); above the reference cats. A cat, which had the age of 12 years and body condition score 3 had a value SDMA showed increased even within the reference range; which is more reliable and trusted with respect to creatinine showed lower values, possibly underestimated due to a decrease in muscle mass. In conclusion, the use of biomarkers is a suitable tool for examining the renal function, and these have proved to be effective in expressing evidence of renal injury.