Avaliação tomográfica da regeneração óssea em coelhos, através do uso de quitosana, hidroxiapatita e gelatina.

Abstract

Tomographic evaluation of bone regeneration in rabbits, using chitosan, hydroxyapatite and gelatin. Due to constant search of medicine for a model of treatment that can accelerate the process of bone regeneration without bringing harm to patients, the present study aimed to evaluate the efficacy of chitosan , gelatin and hydroxyapatite in bone tissue regeneration in rabbits. 8 adult rabbits, 4 males and 4 females, New Zeland, weighing on average 3 kg were used . The animals were subjected to a trial period of 30 days. Where each animal control was called control group ( C ), which was not treated and used as a control, in which an osteotomy was made in the right tibial metaphysis member in orthopedic drill 4mm, and treatment group ( QHG ) which was treated group with the composite satisfaction in their formulation chitosan, hydroxyapatite and gelatin which were introduced in the left tibial metaphysis after osteotomy with the same drill used in the control group. The animals were euthanized at 30 days after surgery. Was performed computed tomography (CT ), 30 days postoperatively according to the euthanasia of animals, aiming to follow the process of bone repair. To compare the groups regarding bone healing Student's t test for normally distributed data or the Mann - Whitney test for data without normal distribution was used. The significance level for all analyzes will be 5 % . Even with no significant difference between groups, the QHG group showed higher radiopacity than group C.