Avaliação de biópsia hepática guiada por ultra-som e bioquímica sérica de asininos (Equus asinus) intoxicados experimentalmente por Crotalaria retusa.

Abstract

In the semi-arid region of Brazil there are problems with the intoxication of horses by ingestion of toxic plants, such as Crotalaria retusa, which cause acute, chronic liver damage triggering clinical signs of hepatic encephalopathy and death. Using four donkeys adults, one as a control and administering three different concentrations of C seed, retusa, being lg, 3g and 5g/kg of live weight of the animals. A guided liver biopsy was performed by ultrasound every 30 days and evaluation of serum enzymes every seven days. a donkey that administration of the highest concentration dose died 10 days after ingestion of the seeds. In the histopathological exams of the biopsies, no alterations suggestive of liver injury, but serum enzymes showed considerable changes. Probably donkeys only present histological manifestations of liver diseases caused by alkaloids pyrrolizidines from C. retusa when there is an intake greater than the administered doses, even thus, there was an increase considered in the AST, GGT and FA enzymes researched, evidencing the occurrence of liver disorder.