Avaliação da cicatrização cutânea por uso de gel à base de nanopartículas de prata em coelhos.

Abstract

The present study has two chapters. In the first chapter the objective is a systematic review was performed to evaluate the application of silver nanoparticles in various wound tests with different substance associations. To perform this review, an online extension survey was used according to the Preferred Report Items Methodology for Systematic Analysis and Meta- Analysis (PRISMA) of articles published and indexed on electronic platforms PubMed and LILACS in the last 10 years. The articles were selected according to the inclusion criteria, totaling three articles that constituted the work. Several combinations with silver nanoparticles were observed in different situations with or without infection. And based on the results found, they were demonstrated as their antibacterial characteristics and anti-inflammatory properties of silver nanoparticles, which are being studied and used in different variations for a better application in the clinical routine. The second chapter objective to evaluate the use of silver nanoparticle-based gel in tissue regeneration in rabbits. It was used 12 animals randomly divided into 2 groups. The animals were divided into group 1 (G24), which consisted of 6 animals, where they were produced as dressings every 24 hours and application of the ointment; Group 2 (G48) consisted of 6 animals whose curative change and ointment application were performed every 48 hours. All animals were their own control (CG). The use of silver nanoparticle based gel results in a good prognosis, biological compatibility with wound bed, brings beneficial changes and contributes to better healing.