Efeito da variação da dose do ioversol na epidurografia em cadelas e emprego de fármacos opióides pela via epidural em cães e gatos.

Abstract

The present study consists of two chapters. In the first chapter, the objective was to evaluate the diffusion area of ioversol 320 mg I/mL, when administered in two different doses, via the lumbosacral epidural route in bitches, also analyzing the possible changes in the physiological parameters caused by the administration. For this, 10 bitches were used, randomly allocated into two groups, in which the contrast was administered at the doses of 0.05 mL/cm and 0.1 mL/cm of the spine. In addition to contrast migration, the following parameters were evaluated: heart rate, electrocardiography, systolic blood pressure, respiratory rate, peripheral oxyhemoglobin saturation, body temperature and skin surface temperature. Such parameters were evaluated before the anesthetic procedure and contrast administration and every 10 minutes after, for one hour. The use of ioversol at doses of 0.05 mL/cm and 0.1 mL/cm provided diffusion through the epidural space that reached the T10 and T5 vertebrae as medians, respectively, without causing adverse effects in the bitches. The second chapter deals with a systematic review on the administration of opioids through the epidural route, carried out in the Pubmed and Science Direct databases, in order to select the most relevant articles on the proposed topic. Fifty articles were found, of which 15 were selected after applying the inclusion criteria, which contained relevant information. Several opioids have already been administered via the epidural route, showing efficacy in controlling postoperative pain, as the duration of the epidural route is prolonged and its adverse effects are reduced.