Tumor de células granulares: relato de caso em paciente jovem.

Abstract

Granular cell tumor is a benign soft tissue neoplasm. The histogenesis of this lesion continues to be discussed, however recent studies point to an origin from the Schwann cells. The granularity nature of tumor cells may be the result of cell senescence due to lysosomal accumulation. The lesion can involve skin and subcutaneous tissue and in the region of the head and neck, the dorsal surface of the tongue is the most affected site. This work reports a case of granular cell tumor arising in the dorsal tongue of an 18-year-old brown woman presenting a solitary, fast-growing, asymptomatic and sessile swelling 2 cm in diameter at clinical examination. After excisional biopsy, a microscopic analysis of massive and poorly demarcated proliferation of eosinophilic and polygonal cells presents small central dark nucleius and abundant granular cytoplasm. Cells were closely associated with muscle striatum. Immunohistochemistry demonstrated a positive staining for S-100 protein in tumor cells, allowing the diagnosis of granular cell tumor. After one year of treatment, there is no relapse.