Avaliação comparativa dos aspectos morfológicos do revestimento epitelial de ceratocistos odontogênicos sindrômicos e não sindrômicos.

Abstract

Odontogenic keratocyst (CO) is a cystic lesion originated in dental lamina remais, characterized by its infiltrative pattern, with high recurrence rates. This lesion may be associated with the Gorlin-Goltz syndrome, which, among other findings, may present multiple COs in the jaws. The aim of this study was to compare the histopathological aspects of the epithelial lining cyst of the Non-Syndromic Odontogenic Keratocyst (CONS) and the syndromic Odontogenic Keratocysts (COS). Methodology: Epithelial thickness analysis was performed in two ways: by counting cell layers and using software Image J to do the measurements. The presence of exocytosis was evaluated and classified according to the presence of inflammatory cells in the epithelial thirds. The mitoses and buddings count was performed throughout the whole epithelium extension. Results: Fifty-four CO cases were included in the sample, of which 30 were CONS and 24 were COS cases. No statistically significant differences in epithelial thickness were identified between groups. The presence of inflammatory cells in the epithelium (exocytosis) was evidenced in a large part of the sample, without significant differences between CONSs and COSs. The count of mitoses and buddings did not find significant statistical differences between the groups. Conclusion: The possible differences attributed to the COSs found in the literature could not be evidenced by the histopathological criteria investigated in the epithelium of the cystic coating of the lesions of this study.