Avaliação de atividade antioxidante da saliva em pacientes com diabetes tipo II.

Abstract

Evaluation of saliva antioxidant activity in patients with type II diabetes. Saliva is a biological fluid produced not inside the salivary glands. Due to the presence of several antioxidant substances in this fluid, it plays an important role in not controlling and modulating oxidative damage in the oral cavity. Objective: analyze the antioxidant capacity of saliva in patients with type II diabetes. Material and methods: The study was conducted with 98 patients, 50 and 48 diabetics and non diabetics. All were between 18 and 80 years old, were of both sexes, non-smokers and patients in the diabetic group had type II diabetes confirmed in their medical records. The research project was approved by the Human Research Ethics Committee of the Alcides Candeia University Hospital. For evaluation of the antioxidant activity were measured the concentration of salivary uric acid and ferrous ion chelating capacity. The data were analyzed by means of the unpaired student “t” test. Graph Pad Prism version 6.0 was used for statistical analyzes. Results: In the analysis of salivary uric acid levels, it was observed that there was no statisticaldifference in relation to this parameter between the control and diabetic groups. When evaluating the total antioxidant activity through the ability to chelate the ferrous ion in saliva, It was observed that the control group presented a significantly higher percentage in relation to the group of diabetic patients. Conclusion: salivary uric acid levels were similar in both groups (diabetics and non-diabetics) Concluding that the presence of diabetes may influence the reduction of salivary antioxidant defense.