Efeito de diferentes concentrações de diacetato de clorexidina em cimentos ionoméricos sobre a biocompatibilidade in vivo.

Abstract

This study focused on testing the null hypothesis that there is no difference between the biocompatibility of orthodontic cement modified by diacetate of chlorhexidine (DC) at different concentrations. Sixty Wistar rats were used males, distributed in 5 groups (n=12), being: Group C (control, tube of polyethylene), Group P (Conventional glass ionomer cement, Precedent) and PD1, PD2 and PD3 groups (Precedent, modified with 1%, 2% and 3% DC, respectively). The animals were sacrificed after 7, 15 and 30 days and the tissues analyzed under optical microscopy for infiltration events inflammation, edema, necrosis, granulation tissue, giant cells, young fibroblasts and collagen fibers. The results were analyzed by the Kruskal-Wallis and Dunn tests (p<0.05). In the initial period, intense infiltration inflammation was demonstrated mainly in the PD1, PD2 and PD3 groups, with statistically significant difference between the Control Group and PD3 (P=0.009) at times of 7, 15 and 30 days. Multinucleated giant cells were shown more present in the PD3 Group, with a statistical difference with the Control Group in the time periods of 7 (P=0.021) and 15 days (P=0.042). The PD3 Group demonstrated the smallest amounts of collagen fibers between the groups, with statistical difference with the control group in the time period of 15 (P=0.049) and 30 days (P=0.029). The null hypothesis was partially accepted. precedent modified with 3% DC influenced more the inflammatory process, cells giants and amount of collagen fibers than concentrations of 1% and 2%.