Desenvolvimento de scaffolds de TiO2 e TiO2/PLA obtidos por fiação por sopro em solução.

Abstract

Nanostructured materials based on titanium dioxide (TiO2) have great potencial for the development of biomaterials due to their excellent physical and chemical characteristics. Thus, the present work aims to produce nanofibrillary scaffolds of TiO2 and hybrid of poly (lactic acid) / titanium dioxide (PLA / TiO2) by solution blow spinning that uses its regeneration of bone tissue. As TiO2 nanofibers were used in the use of ethanol, dimethyl carbonate and titanium isopropoxide (TTIP) with a 1: 1: 0,8 volume ratio, respectively. While the hybrid nanofibers were produced with TTIP and acetic acid in the proportion (by volume) 1.2: 1. TiO2 scaffolds was used by uniaxial compression, using uncalcined and calcined fibers at 500, 600 and 700 ° C. As nanofibers Hybrid cut TiO2 / PLA were placed in the oven at 60 ° C, resulting in a hybrid scaffold consisting of TiO2 and PLA. The TiO2 scaffolds and the hybrid used were characterized by scanning electron microscopy (MEV), X-ray diffraction (DRX), Fourier transform infrared spectroscopy (FTIR), thermogravimetry (TGA), differential thermal analysis (DTA) and computerized microtomography. The morphological analysis showed that the calcined TiO2 nanofibrillary scaffolds presented a smaller number of beads and a uniform morphology. Through the analysis of DRX and FTIR, the formation of anatomical phases was verified at a temperature of 500 ° C and at a temperature of rutile use of 600 ° C. While the hybrid has a band, which indicates its predominantly amorphous behavior. As microtomographic images revealed the TiO2 scaffolds applied at 700 ° C and the hybrid showed an interconnected and highly porous structure. While the scaffolds produced by pressing and calcination showed porosity below 5%.