Produção de chalconas e suas diversas aplicações, com ênfase em suas propriedades farmacológicas.

Abstract

The need for innovation and lack of discovery of new drugs for diseases with absence of proper treatment combined with the bent promoted by industrial competitiveness, composes the main reason for the sharp financial investments by industries, featuring regular event in recent years. The synthetic chalcones shows a rather promising strategy for alternative treatment methods for various diseases, since they provide a range of biological activities that have already been exploited by several research groups all over the world. This review aims the measurement of relevant importance afforded by the characteristic of biological effects of chalcones, also featuring later techniques already established that enable the synthesis of chalcones, both conventional and new techniques, that promotes the optimization process. The most commonly used synthetic strategy for the construction of chalcone core arise from Claisen - Schmidt reactions between aryl ketones and benzaldehyde derivatives, however the adoption of ultrasonic irradiation technique and microwave, and the development of new catalysts, increased the reaction proceeds. Indeed, chalcones are molecules of high industrial potential, presenting relatively simple synthesis and handling, widely described in the literature . The optimization of synthesis, shows better yields of products, and incorporate techniques that reduce production costs and consequently a high profits.