Resistência insulínica e a associação entre doença hepática gordurosa não alcoólica e doença arterial coronariana.

Abstract

Insulin resistance (IR) is a condition in which the normal amounts of insulin produced by the body are inadequate to provide a satisfactory response of insulin action in adipocytes, muscle tissues and liver. Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of IR. Objectives: to evaluate IR and its association with NAFLD and coronary artery disease (CAD), and to describe epidemiological, clinical and laboratory characteristics of patients with IR. Methodology: a statistical analysis of the database derived from the study of patients undergoing coronary angiography (CAG) in order to observe the frequency of NAFLD in patients with coronary artery disease, according to pre-established criteria, versus patients with normal CAG, between February 2009 and January 2011 in the city of Campina Grande (PB). All patients included in this study, after informed consent, were assessed by questionnaire, clinical examination, laboratory tests and ultrasound. Results: HOMA-IR ≥ 3.0 was present in 27.9 % (68 ) of the patients, this condition was associated with a significantly higher average levels of blood glucose and triglycerides, an association of CAD and NAFLD, (metabolic syndrome) MS and type 2 diabetes mellitus (DM2) (p < 0 , 0001), overweight/obesity (p = 0.001) and NAFLD alone (p = 0.015). Patients with RI and an association of CAD and NAFLD has 6.18 times more likely to have hypertension (p = 0.016). Conclusion: patients with insulin resistance had a significant relationship with increased blood glucose levels, overweight and obesity, DM2, SM, hypertriglyceridemia, isolated NAFLD and the presence of CAD and NAFLD association. In insulin-resistant patients who had CAD and NAFLD association, (hypertension) HAS was the only significant risk factor related to this association.