Risco cardiovascular avaliado pelo pathobiological determinants of atherosclerosis in youth em adolecentes: relação com a resistência insulínica.

Abstract

INTRODUCTION: The genesis of cardiovascular diseases begins in childhood through the presence of cardiometabolic risk factors. OBJECTIVES: To evaluate the association of cardiovascular risk and insulin resistance in adolescents from public school. METHODOLOGY: Cross-sectional study, involving 204 adolescents between 15 and 19 years old. Sociodemographic, anthropometric, biochemical and blood pressure variables were evaluated. For the diagnosis of insulin resistance, a HOMA-IR ≥ 2.5 was considered, and for high cardiovascular risk, a score ≥ 5 on the Pathobiological Determinants of Atherosclerosis in Youth score. To assess the association between the variables, the chi-square and Kruskal-wallis tests were used, considering a significance level of 5%. RESULTS: Insulin resistance and high cardiovascular risk were present in 18.0% and 7.8%, respectively. Nutritional status was associated with cardiovascular risk, but not the presence of insulin resistance. The highest HOMA-IR value was associated with the high-risk group. CONCLUSION: A considerable proportion of the evaluated adolescents presented high cardiovascular risk and insulin resistance. HOMA-IR was higher in those at high risk, which may serve as a potentiator for the development of cardiovascular disease.