Intoxicação por Mimosa tenuiflora em cabras prenhes: indução de morte embrionária e falha na indução de malformações.

Abstract

To determine the teratogenic effect of Mimosa tenuiflora, the green plant was administered ad libitum to 12 goats from day 1 to day 30 after mating. None of the goats still pregnant at 30 days of pregnancy, suggesting that M. tenuiflora causes embryonic death. Six goats ingested M. tenuiflora from day 30 to day 60 of pregnancy; two had embryonic loss and the other 4 delivered 7 healthy kids. Other six goats that received the plant from days 60 to 90 of gestation delivered six normal kids. In Group 4, that ingested the plant during days 90-120 o gestation, 5 goats gave birth to 7 normal kid goats and 1 goat aborted two fetuses with 115 days of gestation, after the ingestion of M. tenuiflora for 25 days. Other six goats (Group 5) ingested the plant from day 120 of gestation until parturition, 5 gave birth to 5 normal kid goats and another was found died, after the ingestion of the plant for 13 days (131 days of gestation), without presenting any clinical sign. The goats of Groups 6 (ingestion on days 15-30 of gestation) and Group 7 (ingestion on days 30-45 of gestation) delivered 8 and 10 normal kids, respectively. Six goats of the control Group gave birth to 9 normal kids. It is concluded that M tenuiflora causes embryonic deaths. The failure to induce malformations can be due to the high dose of plant or toxic compound used which caused fetal death in side of malformations. Another possibility is that to induce malformations goats have to ingest the plant during the whole gestation, as it occurs in a previous experiment. Triptamine derivated alkaloids were isolated from the plant but it is unknown I these compounds are embriotoxic or fetotoxic.