Simulação e avaliação de ancoramento do herbicida glifosato a proteína Glutationa S-Transferase PHI 3 em Oryza sativa japônica.

Abstract

Rice is an herbaceous plant in the grass family, from the genus Oryza, which feeds more than half the human population and therefore has great global importance. In spite of such importance, there are just a few studies to minimize the problems intrinsic to the cultivation of these cereals. One of the main limiting factor in the cultivation are rice weeds, due to competitor resources, inherent in a healthy development, the chemical control is still the must importante form of weeds management, where in many cases the cultivar suffers productive losses, by contact with the herbicide. It is known that the superfamily of glutathione s-transferase (GSTs) enzymes confer on rice (Oryza sativa), a biotic and abiotic aesthetic, acts on biotransformation to protect against oxidative stress and excretion of xenobiotics, including herbicide detoxification. It is necessary to explore the mechanism of interaction, as well as the proteins with herbicides in question. Bioinformatics arises with the molecular anchoring technique, which aims to suggest and explore possibles better conditions of molecular interaction, to study and differentiate between a family of ligands or inhibitors. Molecular docking is a broad-spectrum technique with high processing speed and low cost. This work aims to elucidate an interaction of a GST family rice protein and glyphosate herbicide, demonstrating its biotechnological importance and as advantages for agroindustry and agrochemicals industry and for plant genetic improvement, pointing to proteins related to tolerance to herbicides.