Desenvolvimento e aplicação de implante a base da associação de wollastonita, β-TCP e PEGDMA para tratamento de defeito segmentar ósseo em coelhos.

Abstract

Attempts to repair large bone lesions are challenging, to facilitate this process it is possible to use biomaterials that stimulate the regeneration of this tissue, for this it is possible to use isolated or associated materials. The present work proposes to carry out an overview of what is currently being worked on with the application of ethylene glycol dimethacrylate (PEGDMA) on the repair of bone tissue, as well as to present a composite developed with the association of PEGDMA with the beta trisphosphate ceramics of calcium (β-TCP) and Wollastonite to regenerate bone segmental defects in rabbits. In this process, mainly in vivo assays were taken into account. Several evaluations can be performed to monitor the interaction of composites in the body, including imaging and histopathological exams. The positive results reported with the use of composites based on polymers such as polyethylene glycol, could also be observed in the present study, being an excellent option for association, whether with medications, ceramics or other polymers.