Efeitos de pregabalina sobre os tecidos e órgãos endócrinos do aparelho reprodutor masculino.

Abstract

This dissertation comprises a systematic review and a scientific experiment. This is a study on the psychopharmaceutical pregabalin and the deleterious effects caused by its residuais ingestion, through breast milk, on the male reproductive system. In the first chapter, the objective was to investigate, through a systematic review, the relationship of pregabalin with the male reproductive system and the endocrine system. The search was carried out based on the main collection of Web of Science (Clarivate Analytics), in order to select the most relevant articles regarding the proposed theme. A total of 416 articles were found, of which, after applying the inclusion criteria, 16 original and complete scientific studies were selected, with open access, carried out in the period between 2016 and 2021. The studies showed that pregabalin affects hormonal levels (FSH, LH and testosterone) causing changes in spermatogenesis and decreasing the fertility potential of users. The second chapter aimed to evaluate the effects of residual intake of pregabalin in breast milk on the testes of lactating rats. Twenty-four male Wistar rats were used, divided into two experimental groups, a control group (CG) and a treated group (PG) of 12 animals each. The main groups were subdivided into two subgroups each, according to the ages at which they were euthanized, 14 and 21 days of life (CG14, CG21, PG14 and PG21). The sows of the groups treated with pregabalin received 60mg per kilo of the drug orally during the 21 days of lactation, whereas the sows of the control groups received only saline solution. At the established ages, the animals were euthanized and testis samples were collected. Biometric, morphometric and stereological variables were measured. The results indicate that the residual intake of pregabalin in breast milk causes disorganization of the seminiferous epithelium, at 21 days of life there are reductions in morphometric and stereological parameters of the seminiferous tubules, indicating morphological and functional damage to the testicular tissues.