Avaliação da qualidade físico-química de comprimidos de Maleato de Enalapril disponíveis nas farmácias básicas de municípios do Seridó Paraibano.

Abstract

Arterial Hypertension (AH) is a Chronic Noncommunicable Disease (NCD) that is characterized by elevated blood pressure levels. Enalapril maleate belongs to a class of antihypertensives whose main action is the inhibition of Angiotensin I Converting Enzyme (ACE), promoting a decrease in blood pressure. The objective of this work was to evaluate the physical-chemical quality of enalapril maleate tablets from basic pharmacies in six municipalities in the seridó region of Paraíba. Parameters such as visual appearance, average weight, friability, hardness, disintegration and drug content were analyzed, according to the methodologies described by the Brazilian Pharmacopoeia (2019). Eight samples were analyzed, all of which were approved in terms of physical parameters (average weight, hardness, friability and disintegration). In the dosage, which evaluates the drug content, 4 samples presented values outside the limit allowed by the Brazilian Pharmacopoeia (90% to 110%); however, these failed samples may have been influenced by some limitations of the method, which makes the results inconclusive. Therefore, the importance of more robust methods for validating this test is highlighted, ensuring greater confidence in the evaluation of drug quality control. Therefore, quality control of medicines is essential, as it guarantees that the medicine has proven efficacy and safety for the user. Therefore, it is suggested to use this control as a tool for qualifying suppliers and a subsidy for improving the bidding process in the public sector, thus promoting greater security for SUS users.