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http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227| Title: | Anticonvulsant activity of thymoquinone and its structural analogues. |
| Other Titles: | Atividade anticonvulsivante da timoquinona e seus análogos estruturais. |
| ???metadata.dc.creator???: | SOUSA, Damião Pergentino de. NÓBREGA, Franklin Ferreira de Farias. SANTOS, Camila C. M. P. BENEDITO, Rubens Batista. VIEIRA, Ygor W. ULIANA, Marciana Pierina BROCKSON, Timothy John. ALMEIDA, Reinaldo Nóbrega de. |
| Keywords: | Quinonas;Atividade anticonvulsivante;Seizures;Convulsões;Sistema nervoso central;Central nervous system;Structure-activity relationships;Oils;Óleos;Quinones;Anticonvulsant activity;Seizures;Convulsions;Central nervous system;Central nervous system;Structure-activity relationships;Oils |
| Issue Date: | 2011 |
| Publisher: | Universidade Federal de Campina Grande |
| Citation: | SOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; SANTOS, Camila C. M. P.; BENEDITO, Rubens Batista; VIEIRA, Ygor W.; ULIANA, Marciana Pierina; BROCKSON, Timothy John; ALMEIDA, Reinaldo Nóbrega de. Anticonvulsant activity of thymoquinone and its structural analogues. Revista Brasileira de Farmacognosia, v. 21, p. 427-431, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227 |
| ???metadata.dc.description.resumo???: | It has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds. |
| Keywords: | Quinonas Atividade anticonvulsivante Seizures Convulsões Sistema nervoso central Central nervous system Structure-activity relationships Oils Óleos Quinones Anticonvulsant activity Seizures Convulsions Central nervous system Central nervous system Structure-activity relationships Oils |
| ???metadata.dc.subject.cnpq???: | Farmácia. Química. |
| URI: | http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227 |
| Appears in Collections: | Artigos Científicos - CDSA |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| ANTICONVULSANT ACTIVITY OF THYMOQUINONE - ARTIGO DE PERIÓDICO CDSA 2011.pdf | Anticonvulsant activity of thymoquinone and its structural analogues. Artigo de Periódico CDSA 2011 | 322.81 kB | Adobe PDF | View/Open |
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