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Please use this identifier to cite or link to this item: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227
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dc.description.resumoIt has been widely reported that the crude oil of Nigella sativa L., Ranunculaceae, seeds and its major chemical component thymoquinone present anticonvulsant activity. These facts led us to verify the pharmacological potential of five structurally related para-benzoquinones on the pentylenotetrazol-induced seizures model, and establish the structural characteristics that influence the anticonvulsant activity of thymoquinone. The unsubstituted para-benzoquinone was the compound that exhibited the highest potency, while 2-methyl-p-benzoquinone was inactive. It was found that the presence of alkyl groups attached to the ring influence the pharmacological activity of the para-benzoquinones. In addition, the number, position, and size of these groups change the anticonvulsant potency of the compounds.pt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.initialsUFCGpt_BR
dc.subject.cnpqFarmácia.pt_BR
dc.subject.cnpqQuímica.pt_BR
dc.titleAnticonvulsant activity of thymoquinone and its structural analogues.pt_BR
dc.date.issued2011-
dc.identifier.urihttp://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227-
dc.date.accessioned2024-08-08T23:00:04Z-
dc.date.available2024-08-08-
dc.date.available2024-08-08T23:00:04Z-
dc.typeArtigo de Periódicopt_BR
dc.subjectQuinonaspt_BR
dc.subjectAtividade anticonvulsivantept_BR
dc.subjectSeizurespt_BR
dc.subjectConvulsõespt_BR
dc.subjectSistema nervoso centralpt_BR
dc.subjectCentral nervous systempt_BR
dc.subjectStructure-activity relationshipspt_BR
dc.subjectOilspt_BR
dc.subjectÓleospt_BR
dc.subjectQuinonespt_BR
dc.subjectAnticonvulsant activitypt_BR
dc.subjectSeizurespt_BR
dc.subjectConvulsionspt_BR
dc.subjectCentral nervous systempt_BR
dc.subjectCentral nervous systempt_BR
dc.subjectStructure-activity relationshipspt_BR
dc.subjectOilspt_BR
dc.rightsAcesso Abertopt_BR
dc.creatorSOUSA, Damião Pergentino de.-
dc.creatorNÓBREGA, Franklin Ferreira de Farias.-
dc.creatorSANTOS, Camila C. M. P.-
dc.creatorBENEDITO, Rubens Batista.-
dc.creatorVIEIRA, Ygor W.-
dc.creatorULIANA, Marciana Pierina-
dc.creatorBROCKSON, Timothy John.-
dc.creatorALMEIDA, Reinaldo Nóbrega de.-
dc.publisherUniversidade Federal de Campina Grandept_BR
dc.languageengpt_BR
dc.title.alternativeAtividade anticonvulsivante da timoquinona e seus análogos estruturais.pt_BR
dc.identifier.citationSOUSA, Damião Pergentino de; NÓBREGA, Franklin Ferreira de Farias; SANTOS, Camila C. M. P.; BENEDITO, Rubens Batista; VIEIRA, Ygor W.; ULIANA, Marciana Pierina; BROCKSON, Timothy John; ALMEIDA, Reinaldo Nóbrega de. Anticonvulsant activity of thymoquinone and its structural analogues. Revista Brasileira de Farmacognosia, v. 21, p. 427-431, 2011. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37227pt_BR
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