Prospecção in silico de produtos naturais inibidores da enzima de replicação viral NS5 RDRP do vírus do Nilo Ocidental.

Abstract

WNV (West Nile Virus) is a flavivirus, the etiological agent of West Nile Fever zoonosis. It is transmitted by mosquitoes of the Culex genus, and birds are the main reservoir of the virus. This virus is responsible for encephalitis that, in the most severe cases, can cause permanent sequelae which can lead to death. In 2014, the first case of West Nile virus infection in humans was registered in national territory, proving that the virus is already circulating in our country. There is still no vaccine or specific medication against VNO and the efforts against the disease are focused on monitoring reservoirs (birds and domestic animals), combating the vector insect, and palliative treatment of those affected. Within this context, this research proposal aims to select compounds that can be used as antiviral drugs, using the viral replication protein NS5 as a target molecule.