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http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37594| Title: | Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation. |
| Other Titles: | Encaixe molecular das glutationa S-transferases epsilon 2 (GSTE2) do Anopheles gambiae e do Aedes aegypti contra ácido úsnico: uma evidência de conjugação da glutationa. |
| ???metadata.dc.creator???: | MAIA, Rafael Trindade. NADVORNY, Daniela. |
| Keywords: | Anopheles gambiae GSTE2;Aedes aegypti;Molecular modeling;Insecticide resistence;Modelagem molecular;Resistência a inseticidas |
| Issue Date: | 2014 |
| Publisher: | Universidade Federal de Campina Grande |
| Citation: | MAIA, Rafael Trindade; NADVORNY, Daniela. Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation. Brazilian Archives of Biology and Technology (Impresso), v. 57, p. 689-694, 2014. Disponível em: http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37594 |
| Abstract: | The aim of this study was to develop a theoretical model using Anopheles gambiae GSTE2 structure as template for Aedes aegypti GSTE2 by homology modeling Docking simulations were performed for both the enzymes against usnic acid in neutral and anionic forms. Ramachandran plot revealed that 93.9% of the GSTE2 model residues were located on most favored regions. Model evaluation was made by the ANOLEA and GROMOS analysis. Docking results indicated that the enzymes were able to form glutathione-conjugate with usnic acid in both the forms (anionic and neutral). |
| Keywords: | Anopheles gambiae GSTE2 Aedes aegypti Molecular modeling Insecticide resistence Modelagem molecular Resistência a inseticidas |
| ???metadata.dc.subject.cnpq???: | Biologia |
| URI: | http://dspace.sti.ufcg.edu.br:8080/jspui/handle/riufcg/37594 |
| Appears in Collections: | Artigos Científicos - CDSA |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| MOLECULAR DOCKING OF ANOPHELES GAMBIAE ANDE AEDES AEGYPTI - ARTIGO DE PERIÓDICO CDSA 2014.pdf | Molecular docking of Anopheles gambiae and Aedes aegypti glutathione S-transferases epsilon 2 (GSTE2) against usnic acid: an evidence of glutathione conjugation. - Artigo de Periódico CDSA 2014 | 322.69 kB | Adobe PDF | View/Open |
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