Filme de quitosana para liberação controlada de colchicina para tratamento de carcinoma basocelular.

Abstract

Basal cell carcinoma is the most common cancer in the world, and despite its evolution often benign, with high cure rates, sometimes we are faced with more aggressive, invasive cases, destructive and difficult to control. It is known that there have been advances in treatment for these specific cases, such as the Vismodegib, however this drug is still a distant reality for our Brazilian patients who are exposed to high levels of solar radiation in most rural workers from low-income, great difficulty accessibility to the public health system. Therefore, this study suggests an alternative for the control of severe forms of basal cell carcinoma, through the production of a chitosan film doped colchicine known antimitotic substance and with clinical evidence already mentioned in the literature in basal cell carcinoma, transdermally for release controlled drug that allows keep at a steady serum level, enough for their antimitotic, causing selective killing of tumor cells, reducing or extirpating these tumors, with more affordable because it is an inexpensive drug, consequently improving morbidity the disease and the quality of life of these patients. And the results obtained from the characterization showed membranes crystallinity variations (XRD) according to the crosslinking process. By FTIR one can observe some interaction between the drug and amino groups of chitosan. Through optical and electronic microscopy, it can be seen that addition of drug has provided some roughness to the membrane. Also by microscopy verified the inhomogeneous crosslinking of the membrane surface. EDS there was no foreign object the structure of chitosan and the drug. By measuring the wetting angle can be checked increase the hydrophilic profile of the drug by adding the membrane, this profile has been modified by the crosslinking process. From the cytotoxicity assay can be seen that the membrane has some cytotoxicity. This result also demonstrates the potential of chitosan membrane to release the drug, whereas only chitosan membrane shows no toxicity in biological medium, with the toxicity observed in this trial due to the released drug.