Investigação de possíveis interações entre medicamentos em prescrições do Hospital Municipal de Cuité.

Abstract

It is defined as drug interaction when the effects and / or toxicity of one drug are altered by the presence of another. Regardless of whether it results in positive or negative effects, the interactions are generally unpredictable and undesirable in pharmacotherapy. The relationship between the great demand for prescription drugs and the potential risk of interactions between these drugs is frequent, which is still a problem today in public and private hospitals. possibilities of adverse drug-drug interaction risks in prescriptions of patients admitted to the Hospital Municipal Cuité. A descriptive research was carried out, with a quantitative and qualitative approach. The data collection was done in the period from April to July 2017, from the medical prescriptions of the hospital. The data were collected through a specific form for this purpose. The Drug-Reax System of the Micromedex® Health Series software was used to identify the potential interactions. Among the 325 prescriptions evaluated, 120 (36.92%) presented some interaction, totaling 214 potential interactions. The profile of the majority of the interactions found was: mostly female, higher degree of severity, reasonable documentation and unspecified onset of action. A median of 3.59 prescription medications was observed. The majority of patients who used between 6 and 10 drugs had some type of interaction. Polypharmacy can be considered a risk factor for the occurrence of interactions. The obtained results show that the emergence of interactions in the hospital has a high prevalence. The use of combinations that may cause drug interactions is justified by its risk / benefit, which should be evaluated by the pharmacist and health staff. To reduce the occurrence of possible interactions, it is essential to monitor prescriptions and it is necessary for health professionals to be aware of the mechanisms of action of potential interactions for continuous and effective monitoring of patients, thus improving clinical management and avoiding complications that may occur.