Efeito promissor do linalol frente á patogenicidade de Trichophyton rubrum resistentes a fluconazol.

Abstract

Trichophyton rubrum is responsible for high rates of dermatophytosis. This is a type of fungal infection that affects keratinized tissues such as nails, skin and scalp. In this way, it is necessary to search for studies with new therapeutic agents, with emphasis on natural products such as terpenes. This study investigated the activities of linalool, an alcoholic monoterpene with potential antifungal activity, against clinical isolates of T. rubrum. Initially, minimal inhibitory concentration (MIC) of linalool and ketoconazole were determined by microdilution in RPMI 1640 medium. The action of linalool at concentrations of 128 μg / mL (1 / 2MIC), 256 μg / mL ), 512 μg / mL (2XMIC), and for azole ketoconazole in 4 μg / mL (1 / 2MIC), 8 μg / mL (MIC), 16 μg / mL (2xMIC) on the mycelial growth of T. rubrum LM 305 , which presented inhibitory activity differing statistically from the control (p <0.05). Subsequently, the effect of the test drug on conidiogenesis was analyzed, showing inhibitory effect (p <0.05), highlighting its concentration of 512 μg / mL, which was similar to that of ketoconazole. Finally, antifungal activity on conidia germination (p <0.05) was observed, and once again, linalool presented a similar inhibitory action to ketoconazole. Thus, it can be concluded that linalool is an antifungal agent with great potential against T. rubrum, an important agent in dermatophytosis.