Desenvolvimento de metodologia de compressão para produção de comprimidos de AAS nas aulas práticas de tecnologia farmacêuticas.

Abstract

Tablets are the most widely used pharmaceutical form in the world, due to its many advantages offered to both the industry and the patient. Its manufacturing is an industrial process composed of several stages, most of them requiring the use of robust equipment, making this practice difficult to simulate in the classroom environment. Therefore the aim of this work is the development of AAS tablets, using a small scale compression methodology for practical classes of solid dosage forms, with the purpose of demonstrating the manufacture of tablets in all its stages, from the synthesis to the quality assays, unifying theoretical knowledge of the various disciplines involved in this production process as experimental organic chemistry with the synthesis of the active principle, the pharmacotechnics with the study of the excipients and formulation, and the discipline of quality control of drugs with the post-manufacture tests. The following tests were performed: Appearance, average weight, hardness and friability. The batch presented acceptable appearance being this white color, circular and flat forms free of foreign material. The mean weight was 2,467 g, within the acceptable range, being this result less than 5% as recommended in pharmacopoeia. None of the tablets tested had a hardness higher than 30 Newton recommended in pharmacopoeia, demonstrating that the process did not present adequate compression. As for friability, the tablets presented a loss of 23% of mass after the test, being this value superior to 1.5% recommended in pharmacopoeia. However, the practice of making the tablets has brought to the student more proximity to such an industrial process, and with that, materializing his multidisciplinary theoretical knowledge, resulting in the formation of a professional more prepared for the job market.