New Delhi Metalobetalactamase: uma revisão bibliográfica.

Abstract

Numerous are problems which affected the scope health in all the world, including the existence of bacteria multiresistant. This problem comes growing up at the to long to time intensenly because of the irrational use of drugs, resulting on the development of mechanisms of resistance by the bacteria, for example, the production of enzymes how the New Delhi Metalo-β-lactamase (NDM-1).This enzyme had yours occurrence reported for the first time in 2009 in New Delhi, in India, since then numerous reports there are occurred all over the world, including in Brazil. With the objective of to examine the mechanism action from that enzyme, to verify where occur the main cases, which are the bacteria that expressing the enzyme, and if there is prospects of development of drugs that may be used in the treatment infections by bacteria carrier of NDM-1, was performed a literature review about of theme concerned. From the study realized, was possible to observe that enzyme present a mechanism of action complex involving two ways. Among the bacteria that carted NDM-1, the Klebsiella pneumoniae and Escherichia coli were the most frequently reported. Case reports involving NDM-1 occurred worldwide, however, with more intensity in Asia, Africa and Europe. Preventive measures were adopted in numerous countries, since it still are not developed one inhibitor effective able to be adopted in clinical practice. Studs focus on discovering of inhibitors already in progress and results very positive. However, the problem of resistance is still very far away to be resolved.