Análise da toxicidade de Chloris gayana Kunth (POACEAE) por meio da determinação da CL50.

Abstract

The healing power of plants is as old as the emergence of the human species on earth. However, the indiscriminate use of these can bring risks, making it important to carry out toxicity tests in the search for an effective therapy. Several species of popular known use of bioactive plants have toxic properties, and should be careful not only in the correct identification of the species at the time of acquisition, as well as the dosages to avoid health risks. Based on these facts, the following study aimed to determine the LC50 Chloris gayana Kunth (Poaceae) as bioactivity parameter through bioassay Artemia salina Leach. This is based on the use of A. salina in their larval stage, to evaluate the toxicity of extracts and compounds, avoiding the suffering of larger animals, such as rodents. It's a quick methodology, easy, inexpensive and reliable, which provides greater security in future studies. The test was performed in triplicate and repeated at least three experiments with the crude extract and two phases (water-alcohol and hexane) originating from C. gayana. After the tests, was obtained as results for the species C. gayana, and this showed that both the ethanol extract as for phases tested C. gayana were considered nontoxic. Thus, there is a need of further studies in order to identify substances that prove the bioactive potential of this species.