Análise físico-química de amostras de solução oral de paracetamol comercializadas no município de Cuité - PB.

Abstract

Paracetamol is classified as a non-steroidal analgesic having an effective analgesic and antipyretic the same time, in addition to being the drug of choice for treatment in children. Paracetamol is one of most prescription medicines marketed in Brazil, besides being multiple component formulations. High consumption of paracetamol is due to the low price at which it is sold and the large number of laboratories that produce it. The big problem with this production is that often the development of the drug does not occur properly, not getting to meet even the minimum requirements defined by good manufacturing practices. Another point at issue is the lack of consumer knowledge, the vast majority of the time did not realize the problems that were arising from the use of the product, such as adverse reactions or even ineffective action of the same. Thus, this study aimed to evaluate the most marketed brands of paracetamol, oral solution available in community pharmacies Cuité-PB with respect to compliance with the parameters and specifications described in official literature. Five brands were chosen, which are composed by the reference product (R), two brands of generic drugs (G1 and G2) and two brands of similar products (S1 and S2). The tests were performed in the laboratory of quality control, the Federal University of Campina Grande, PB-Campus Cuité.All brands analyzed were adopted in physico-chemical tests for determination of volume and pH. In the drip test, all brands are deprecated, in the inquiry number of drops per milliliter, except the generic drug, which obtained results within the amount described in Bull. In the assay test R and S1 brands are deprecated. In determining the amount of drug per drop (%) were disapproved the scoring R, G1 and G2. The S2 brand was the drug that was approved in a greater number of tests. The remaining tags were approved by the same amount of testing. Through analysis of the inserts of the brands we noticed they all had to be ambiguous and often confusing