SOUZA, D. R. S.; http://lattes.cnpq.br/5559511348013974; SOUZA, Diego Ramon dos Santos.
Resumo:
Among the heterocyclic compounds, the 1,3,4-oxadiazole represents an important unit forthe development of new drugs, since compounds containing this unit present a broad spectrum of biological activities such as antibacterial, antifungal, analgesic, anti- inflammatory, antiviral, antitumor, antihypertensive, anticonvulsant, etc. The present work describes the synthesis, characterization and study oh antibacterial of 1,3,4-oxadiazoles, that were obtained as racemic mixture from the reaction of cyclization of N-acylhydrazones using aceticanhydride.All compounds were characterized using1H and 13C NMR spectroscopic techniques. In the evaluation of the in vitro antibacterial activity, some of the 1,3,4-oxadiazole synthesized exhibited efficient activity against strains of Staphylococcus aureus, Escherichia coli, and especially Pseudomonas aeruginosa, where all synthesized 1,3,4-oxadiazole showed activity antibacterial, suggesting that these compounds can provide a new source for developing specific drugs to combat this microorganism.