TRÓCOLLI, R.; http://lattes.cnpq.br/7531639738258151; TRÓCOLLI, Rossanna.
Resumo:
Diabetes Melittus appears as a worldwide epidemic, as the most frequent disorder
that involves the metabolism of carbohydrates and is characterized by the increased
rate of glucose in the blood, called hyperglycemia. It is a disease resulting from the
lack of production or the deficit action of insulin. Its treatment is insulin therapy.
Works using the Chitosan as carrier of insulin are considered promising as an
alternative to the route of administration. Chitosan is a natural polysaccharide,
biocompatible and biodegradable. In this context, the present study aimed to develop
and evaluate conjugated Chitosan and Chitosan biofilms/insulin. The Biofilms were
developed by dip-coating method and characterized by x-ray Diffraction (DRX),
Spectroscopy in the region of Fourier transform infrared (FTIR), Optical
Microscopy(MO), Scanning Electron Microscopy (SEM), Energy Dispersive
Spectroscopy/x-ray (EDS) and Wettability by Measuring Contact Angle. The
technique of DRX demonstrated change in character of biodegradable thermoplastic
Chitosan with the presence of insulin. With FTIR, the interaction between Chitosan
and insulin was identified. It was possible to realize, through techniques of MO and
MEV, change in morphology of membrane containing insulin when compared to pure
Chitosan, with the presence of granular particles of varying sizes. The chemical
elements already present in Chitosan and insulin were detected by EDS technique
and, in the testing of surface tension, it was possible to observe an increase in the
hydrophilic character of the biofilms containing insulin in comparison to those of pure
Chitosan. Based on the results obtained, it is concluded that there is evidence of the
incorporation of insulin to the biofilm of Chitosan indicating possibilities for use in less
invasive treatments in the future.