Resistência bacteriana de isolados de uroculturas positivas no Hospital Universitário Alcides Carneiro em Campina Grande / PB.

Abstract

Urinary tract infection (UTI) is the second most common infection in the population, and more prevalent in hospital. The absence of information for performing a specific treatment can result in inadequate empirical therapy consequently in therapeutic failure. This study evaluated the prevalence microbial in urocultures, describing characteristics of the patient and antimicrobial susceptibility profile of the positive samples in HUAC in Campina Grande-PB. It was exploratory research with a quantitative approach, based on information registered on assessment sheets for patients with clinical suspicion of UTI in the period July-December 2012. Of the 554 urine cultures performed, 124 (22.4%) were positive for microbial growth. In outpatient Escherichia coli showed the highest prevalence (61.8%), followed by Klebsiella pneumoniae (8.8%). At the hospital, the most prevalent was Klebsiella pneumoniae (27.8%) followed by Escherichia coli (26.7 %). The female sex had a higher prevalence in women over 40 years (44.2%) in outpatient and over 61 years in hospitalized patients. As for males, there was a higher prevalence in individuals over 71 years both as a hospital outpatient. A single strain was positive for ESBL production in the community and 11 (44%) for internal. Ampicillin showed the highest percentage of resistance (50%) in the outpatient, followed by nalidixic acid, sulfamethoxazole/trimethoprim, fluoroquinolones and cephalosporins. Ampicillin also showed a higher percentage (96%) of the internal resistance, followed by sulfamethoxazole/trimethoprim, quinolones, monobactans, ampicillin/sulbactam, cephalosporins, carbapenems and aminoglycosides. The testing of antimicrobial susceptibility may induce more effective therapy, preventing inappropriate use, which usually causes an increasing microbial resistance. The implementation of protocols for therapeutic use of antimicrobials, seeking to standardize the use, along with the results of susceptibility testing may allow a reduction of antimicrobial resistance in this hospital.