Preparação e caracterização de filmes híbridos de quitosana a partir do ZnAl1,9Eu0,05O4 visando aplicação na biomedicina.

Abstract

Given the current global need to develop materials that present new clinical applications in medicine, especially in imaging, have given prominence by the scientific community, the development of hybrid materials formed by combining optimized properties between inorganic nanoparticles and a polymer matrix. Thus, the surface of the inorganic nanoparticles of ZnAI204 and ZnAI19Euo,o504 were modified with 3-aminopropyltrimethoxysilane silane agent to improve the interaction among the inorganic/organic compound. Subsequently, the nanoparticles were used as filler for the development of hybrid films of chitosan/ZnAI204 and chitosan/ ZnAh 9Eu0,05O4 obtained by the solvent evaporation method at concentrations of 1:1, 1:3 and 1:5, respectively. Both inorganic nanoparticles of ZnAI204 and ZnAI1]9Eu0,05O4 as the hybrid films were characterized by XRD, SEM, FTIR; TGA/DTA and excitation and emission Spectroscopy. By XRD diffractograms it was observed that both nanoparticles (NPs) of ZnAI204 as luminescent nanoparticles (NPLs) of ZnAI19Euo,o504 howed the phase of ZnAI204 . The hybrid films of chitosan/ZnAI204 and chitosan/ZnAli,9Eu0,05O4 showed peaks associated with ZnAI204 and bands relating to chitosan. The FTIR spectra of NPs of ZnAI204 and NPLs of ZnAI19Eu0,05O4 revealed the presence of bands ZnAI204 . For the hybrid films of chitosan/ZnAI204 and chitosan/ZnAh 9Eu0.05O4 it was observed the tendency for the band that confirms the formation of ZnAI204 and bands of chitosan overlapping bands of silane agent groups. By TGA/DTA curves it was seen that the addition of nanoparticles of ZnAI204 and ZnAh 9Eu0,05O4 caused an increase in thermal stability of the hybrid films of chitosan/ZnAI204 and chitosan/ZnAI19Eu0,05O4 as compared to chitosan films. ZnAI204 and ZnAh 9Eu0,05O4. By SEM it was observed that agglomerates and nanoparticles of ZnAI204 and s ZnAh,9Eu0,05O4 howed appearance irregular shape and variable and the presence of a few pores. The hybrid films of chitosan/ZnAI204 and chitosan/ZnAh 9Eu0,05O4 showed a protruding structure, with clusters on the surface and encapsulated in chitosan. By means of the emission and excitation Spectra was observed that the hybrid films of chitosan/ZnAI204 and chitosan/ ZnAI1i9Eu0,05O4 presented promising luminescent properties for application in the field. The optimized luminescence properties occurred due to the greater intensity of transition of 5D0—>7F2 of the Europium with emission in the red region, presenting thus promising properties for application as biological sensors in biomedicine.